, 2006; Sawaya and Kraut, 1997; Figure 1—figure dietary supplement 1), we predicted the mutational landscape of DHFR to generally be constrained by the prerequisite to adopt these unique conformations. Additionally, prior perform experienced recommended DHFR is impacted by cellular constraints for example protein high quality Command (Bershtein et al., 2013) as well as Develop-up of a poisonous metabolic intermediate (Schober et al., 2019). We hence envisioned deep mutational scanning to expose a extremely constrained mutational landscape for DHFR that will contrast Using the mutational tolerance noticed in other units.
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